Date | Time* | Comp |
| Home | Score | Away |
|
| Opposition | Result | Venue | TV/Attendance |
|
September 2021 |
Fri 24 Sep | 19:35 | URC-IC,WC |  | Cardiff Rugby | 33 - 21 | Connacht Rugby |  | A |
| L 21-33 | Cardiff Arms Park | 5,292 |
|
Fri 24 Sep | 19:35 | URC-IC,SIC |  | Ulster Rugby | 35 - 29 | Glasgow Warriors |  | H |
| W 35-29 | Kingspan Stadium | 10,000 |
|
Sat 25 Sep | 17:15 | URC-IC,SAC |  | Leinster Rugby | 31 - 3 | Vodacom Bulls |  | H |
| W 31-3 | Aviva Stadium | 19,419 |
|
Sat 25 Sep | 19:35 | URC-IC,SAC |  | Munster Rugby | 42 - 17 | Cell C Sharks |  | H |
| W 42-17 | Thomond Park | 11,418 |
|
October 2021 |
Fri 1 Oct | 19:35 | URC-IC,SAC |  | Connacht Rugby | 34 - 7 | Vodacom Bulls |  | H |
| W 34-7 | Sportsground | 3,007 |
|
Sat 2 Oct | 18:15 | URC-IC,SIC |  | Zebre Parma | 3 - 36 | Ulster Rugby |  | A |
| W 36-3 | Stadio Sergio Lanfranchi | 1,400 |
|
Sat 2 Oct | 19:35 | URC-IC,SAC |  | Munster Rugby | 34 - 18 | DHL Stormers |  | H |
| W 34-18 | Thomond Park | 10,723 |
|
Sun 3 Oct | 14:00 | URC-IC,WC |  | Dragons | 6 - 7 | Leinster Rugby |  | A |
| W 7-6 | Rodney Parade | 5,043 |
|
Fri 8 Oct | 19:35 | URC-IC,SIC |  | Ulster Rugby | 28 - 8 | Benetton Rugby |  | H |
| W 28-8 | Kingspan Stadium | 10,582 |
|
Sat 9 Oct | 13:00 | URC-IC,SIC |  | Leinster Rugby | 43 - 7 | Zebre Parma |  | H |
| W 43-7 | RDS Arena | 10,400 |
|
Sat 9 Oct | 17:15 | URC-IC,WC |  | Connacht Rugby | 22 - 35 | Dragons |  | H |
| L 22-35 | Sportsground | 3,109 |
|
Sun 10 Oct | 14:00 | URC-IC,WC |  | Scarlets | 13 - 43 | Munster Rugby |  | A |
| W 43-13 | Parc y Scarlets | 6,336 |
|
Fri 15 Oct | 19:35 | URC-IC,SAC |  | Ulster Rugby | 26 - 10 | Emirates Lions |  | H |
| W 26-10 | Kingspan Stadium | 11,412 |
|
Sat 16 Oct | 17:15 | URC-IC,WC |  | Leinster Rugby | 50 - 15 | Scarlets |  | H |
| W 50-15 | RDS Arena | 14,055 |
|
Sat 16 Oct | 19:35 | URC-IC |  | Munster Rugby | 20 - 18 | Connacht Rugby |  | H |
| W 20-18 | Thomond Park | 17,198 |
|
Fri 22 Oct | 19:35 | URC-IC,SIC |  | Glasgow Warriors | 15 - 31 | Leinster Rugby |  | A |
| W 31-15 | Scotstoun Stadium | 7,246 |
|
Sat 23 Oct | 17:15 | URC-IC |  | Connacht Rugby | 36 - 11 | Ulster Rugby |  | H |
| W 36-11 | Aviva Stadium | 9,875 |
|
Sat 23 Oct | 19:35 | URC-IC,WC |  | Ospreys | 18 - 10 | Munster Rugby |  | A |
| L 10-18 | Swansea.com Stadium | 5,678 |
|
November 2021 |
Fri 26 Nov | 19:35 | URC-IC,WC |  | Connacht Rugby | 46 - 18 | Ospreys |  | H |
| W 46-18 | Sportsground | 5,025 |
|
Sat 27 Nov | 20:00 | URC-IC |  | Leinster Rugby | 10 - 20 | Ulster Rugby |  | H |
| L 10-20 | RDS Arena | 14,625 |
|
December 2021 |
Fri 3 Dec | 19:45 | URC-IC |  | Leinster Rugby | 47 - 19 | Connacht Rugby |  | H |
| W 47-19 | RDS Arena | 14,127 |
|
Sat 4 Dec | 15:00 | URC-IC,WC |  | Ospreys | 19 - 13 | Ulster Rugby |  | A |
| L 13-19 | Swansea.com Stadium | 5,695 |
|
January 2022 |
Sat 1 Jan | 17:15 | URC-IC |  | Connacht Rugby | 10 - 8 | Munster Rugby |  | H |
| W 10-8 | Sportsground | 3,064 |
|
Sat 8 Jan | 19:35 | URC-IC |  | Munster Rugby | 18 - 13 | Ulster Rugby |  | H |
| W 18-13 | Thomond Park | 5,000 |
|
Fri 28 Jan | 19:35 | URC-IC,WC |  | Ulster Rugby | 27 - 15 | Scarlets |  | H |
| W 27-15 | Kingspan Stadium | 9,542 |
|
Sat 29 Jan | 14:55 | URC-IC,SIC |  | Connacht Rugby | 20 - 42 | Glasgow Warriors |  | H |
| L 20-42 | Sportsground | 4,527 |
|
Sat 29 Jan | 18:00 | URC-IC,SIC |  | Zebre Parma | 17 - 34 | Munster Rugby |  | A |
| W 34-17 | Stadio Sergio Lanfranchi | 1,000 |
|
Sat 29 Jan | 19:35 | URC-IC,WC |  | Cardiff Rugby | 29 - 27 | Leinster Rugby |  | A |
| L 27-29 | Cardiff Arms Park | 6,846 |
|
February 2022 |
Fri 4 Feb | 20:15 | URC-IC |  | Ulster Rugby | 32 - 12 | Connacht Rugby |  | H |
| W 32-12 | Kingspan Stadium | 12,470 |
|
Fri 11 Feb | 18:00 | URC-IC,SIC |  | Leinster Rugby | 26 - 7 | Edinburgh Rugby |  | H |
| W 26-7 | RDS Arena | 8,559 |
|
Fri 11 Feb | 20:15 | URC-IC,SIC |  | Glasgow Warriors | 13 - 11 | Munster Rugby |  | A |
| L 11-13 | Scotstoun Stadium | 6,238 |
|
Fri 18 Feb | 19:35 | URC-IC,SIC |  | Munster Rugby | 34 - 20 | Edinburgh Rugby |  | H |
| W 34-20 | Thomond Park | 11,791 |
|
Sat 19 Feb | 17:00 | URC-IC,WC |  | Leinster Rugby | 29 - 7 | Ospreys |  | H |
| W 29-7 | RDS Arena | 11,586 |
|
Sat 19 Feb | 19:35 | URC-IC,WC |  | Scarlets | 23 - 29 | Connacht Rugby |  | A |
| W 29-23 | Parc y Scarlets | 5,566 |
|
Sun 20 Feb | 14:00 | URC-IC,WC |  | Dragons | 0 - 12 | Ulster Rugby |  | A |
| W 12-0 | Rodney Parade | 3,892 |
|
Fri 25 Feb | 19:35 | URC-IC,SAC |  | Leinster Rugby | 21 - 13 | Emirates Lions |  | H |
| W 21-13 | RDS Arena | 10,469 |
|
Sat 26 Feb | 13:00 | URC-IC,SAC |  | Connacht Rugby | 19 - 17 | DHL Stormers |  | H |
| W 19-17 | Sportsground | 3,504 |
|
March 2022 |
Fri 4 Mar | 19:35 | URC-IC,SIC |  | Edinburgh Rugby | 56 - 8 | Connacht Rugby |  | A |
| L 8-56 | DAM Health Stadium | 6,116 |
|
Fri 4 Mar | 19:35 | URC-IC,WC |  | Ulster Rugby | 48 - 12 | Cardiff Rugby |  | H |
| W 48-12 | Kingspan Stadium | 11,559 |
|
Sat 5 Mar | 13:55 | URC-IC,SIC |  | Benetton Rugby | 17 - 61 | Leinster Rugby |  | A |
| W 61-17 | Stadio Monigo | 1,932 |
|
Sat 5 Mar | 17:15 | URC-IC,WC |  | Munster Rugby | 64 - 3 | Dragons |  | H |
| W 64-3 | Thomond Park | 11,853 |
|
Sat 12 Mar | 16:05 | URC-IC,SAC |  | Vodacom Bulls | 29 - 24 | Munster Rugby |  | A |
| L 24-29 | Loftus Versfeld | 2,000 |
|
Sat 12 Mar | 19:35 | URC-IC |  | Ulster Rugby | 18 - 13 | Leinster Rugby |  | H |
| W 18-13 | Kingspan Stadium | 16,274 |
|
Sat 19 Mar | 14:00 | URC-IC,SAC |  | Emirates Lions | 23 - 21 | Munster Rugby |  | A |
| L 21-23 | Emirates Airline Park | 2,000 |
|
Fri 25 Mar | 19:35 | URC-IC,SIC |  | Munster Rugby | 51 - 22 | Benetton Rugby |  | H |
| W 51-22 | Musgrave Park | 6,136 |
|
Sat 26 Mar | 15:00 | URC-IC,SAC |  | DHL Stormers | 23 - 20 | Ulster Rugby |  | A |
| L 20-23 | DHL Stadium | 3,544 |
|
Sat 26 Mar | 19:35 | URC-IC |  | Connacht Rugby | 8 - 45 | Leinster Rugby |  | H |
| L 8-45 | Sportsground | 8,126 |
|
April 2022 |
Sat 2 Apr | 13:00 | URC-IC,SIC |  | Benetton Rugby | 17 - 21 | Connacht Rugby |  | A |
| W 21-17 | Stadio Monigo | 2,348 |
|
Sat 2 Apr | 14:00 | URC-IC,SAC |  | Vodacom Bulls | 34 - 16 | Ulster Rugby |  | A |
| L 16-34 | Loftus Versfeld | 19,436 |
|
Sat 2 Apr | 19:00 | URC-IC |  | Munster Rugby | 19 - 34 | Leinster Rugby |  | H |
| L 19-34 | Thomond Park | 20,657 |
|
Fri 22 Apr | 19:35 | URC-IC |  | Ulster Rugby | 17 - 24 | Munster Rugby |  | H |
| L 17-24 | Kingspan Stadium | 12,131 |
|
Sat 23 Apr | 16:05 | URC-IC,SAC |  | Emirates Lions | 30 - 33 | Connacht Rugby |  | A |
| W 33-30 | Emirates Airline Park | 3,897 |
|
Sat 23 Apr | 18:15 | URC-IC,SAC |  | Cell C Sharks | 28 - 23 | Leinster Rugby |  | A |
| L 23-28 | Hollywoodbets Kings Park | 21,823 |
|
Fri 29 Apr | 19:35 | URC-IC,WC |  | Munster Rugby | 42 - 21 | Cardiff Rugby |  | H |
| W 42-21 | Musgrave Park | 7,325 |
|
Sat 30 Apr | 16:05 | URC-IC,SAC |  | Cell C Sharks | 41 - 21 | Connacht Rugby |  | A |
| L 21-41 | Hollywoodbets Kings Park | 10,987 |
|
Sat 30 Apr | 18:15 | URC-IC,SAC |  | DHL Stormers | 20 - 13 | Leinster Rugby |  | A |
| L 13-20 | DHL Stadium (Green Point) | 13,156 |
|
Sat 30 Apr | 19:35 | URC-IC,SIC |  | Edinburgh Rugby | 10 - 16 | Ulster Rugby |  | A |
| W 16-10 | DAM Health Stadium | 7,774 |
|
May 2022 |
Fri 20 May | 19:35 | URC-IC,SAC |  | Ulster Rugby | 24 - 21 | Cell C Sharks |  | H |
| W 24-21 | Kingspan Stadium | 12,739 |
|
Sat 21 May | 17:00 | URC-IC,SIC |  | Connacht Rugby | 22 - 20 | Zebre Parma |  | H |
| W 22-20 | Sportsground | 4,127 |
|
Sat 21 May | 19:15 | URC-IC |  | Leinster Rugby | 35 - 25 | Munster Rugby |  | H |
| W 35-25 | Aviva Stadium | 32,411 |
|
June 2022 |
Fri 3 Jun | 19:35 | URC-QF |  | Ulster Rugby | v | Munster Rugby |  | H |
|
| Kingspan Stadium |
|
|
Sat 4 Jun | 15:15 | URC-QF |  | Leinster Rugby | v | Glasgow Warriors |  | H |
|
| RDS Arena |
|
|
|