| Date | Time* | Comp |
| Home | Score | Away |
|
| Opposition | Result | Venue | TV/Attendance |
|
|---|
| September 2021 |
| Fri 24 Sep | 19:35 | URC-IC,WC |  | Cardiff Rugby | 33 - 21 | Connacht Rugby |  | A |
| L 21-33 | Cardiff Arms Park | 5,292 |
|
| Fri 24 Sep | 19:35 | URC-IC,SIC |  | Ulster Rugby | 35 - 29 | Glasgow Warriors |  | H |
| W 35-29 | Kingspan Stadium | 10,000 |
|
| Sat 25 Sep | 17:15 | URC-IC,SAC |  | Leinster Rugby | 31 - 3 | Vodacom Bulls |  | H |
| W 31-3 | Aviva Stadium | 19,419 |
|
| Sat 25 Sep | 19:35 | URC-IC,SAC |  | Munster Rugby | 42 - 17 | Cell C Sharks | | H |
| W 42-17 | Thomond Park | 11,418 |
|
| October 2021 |
| Fri 1 Oct | 19:35 | URC-IC,SAC | | Connacht Rugby | 34 - 7 | Vodacom Bulls | | H |
| W 34-7 | Sportsground | 3,007 |
|
| Sat 2 Oct | 18:15 | URC-IC,SIC |  | Zebre Parma | 3 - 36 | Ulster Rugby | | A |
| W 36-3 | Stadio Sergio Lanfranchi | 1,400 |
|
| Sat 2 Oct | 19:35 | URC-IC,SAC | | Munster Rugby | 34 - 18 | DHL Stormers |  | H |
| W 34-18 | Thomond Park | 10,723 |
|
| Sun 3 Oct | 14:00 | URC-IC,WC |  | Dragons | 6 - 7 | Leinster Rugby | | A |
| W 7-6 | Rodney Parade | 5,043 |
|
| Fri 8 Oct | 19:35 | URC-IC,SIC | | Ulster Rugby | 28 - 8 | Benetton Rugby |  | H |
| W 28-8 | Kingspan Stadium | 10,582 |
|
| Sat 9 Oct | 13:00 | URC-IC,SIC | | Leinster Rugby | 43 - 7 | Zebre Parma | | H |
| W 43-7 | RDS Arena | 10,400 |
|
| Sat 9 Oct | 17:15 | URC-IC,WC | | Connacht Rugby | 22 - 35 | Dragons | | H |
| L 22-35 | Sportsground | 3,109 |
|
| Sun 10 Oct | 14:00 | URC-IC,WC |  | Scarlets | 13 - 43 | Munster Rugby | | A |
| W 43-13 | Parc y Scarlets | 6,336 |
|
| Fri 15 Oct | 19:35 | URC-IC,SAC | | Ulster Rugby | 26 - 10 | Emirates Lions |  | H |
| W 26-10 | Kingspan Stadium | 11,412 |
|
| Sat 16 Oct | 17:15 | URC-IC,WC | | Leinster Rugby | 50 - 15 | Scarlets | | H |
| W 50-15 | RDS Arena | 14,055 |
|
| Sat 16 Oct | 19:35 | URC-IC | | Munster Rugby | 20 - 18 | Connacht Rugby | | H |
| W 20-18 | Thomond Park | 17,198 |
|
| Fri 22 Oct | 19:35 | URC-IC,SIC | | Glasgow Warriors | v | Leinster Rugby | | A |
|
| Scotstoun Stadium | Prem/TG4 | Live |
| Sat 23 Oct | 17:15 | URC-IC | | Connacht Rugby | v | Ulster Rugby | | H |
|
| Aviva Stadium | TG4/Prem |
|
| Sat 23 Oct | 19:35 | URC-IC,WC |  | Ospreys | v | Munster Rugby | | A |
|
| Swansea.com Stadium | S4C/RTE/Prem |
|
| November 2021 |
| Fri 26 Nov | 19:35 | URC-IC,WC | | Connacht Rugby | v | Ospreys | | H |
|
| Sportsground | RTE/BBCW/Pr |
|
| Sat 27 Nov | 19:45 | URC-IC,SAC | | Vodacom Bulls | v | Munster Rugby | | A |
|
| Loftus Versfeld | SS/TG4/Prem |
|
| Sat 27 Nov | 20:00 | URC-IC | | Leinster Rugby | v | Ulster Rugby | | H |
|
| RDS Arena | RTE/Prem |
|
| December 2021 |
| Fri 3 Dec | 19:45 | URC-IC | | Leinster Rugby | v | Connacht Rugby | | H |
|
| RDS Arena | TG4/Prem |
|
| Sat 4 Dec | 15:00 | URC-IC,WC | | Ospreys | v | Ulster Rugby | | A |
|
| Swansea.com Stadium | Prem |
|
| Sat 4 Dec | 17:30 | URC-IC,SAC | | Emirates Lions | v | Munster Rugby | | A |
|
| Emirates Airline Park | SS/RTE/Prem |
|
| Sun 26 Dec | 17:15 | URC-IC | | Ulster Rugby | v | Connacht Rugby | | H |
|
| Kingspan Stadium | BBC NI/TG4/Prem |
|
| Sun 26 Dec | 19:35 | URC-IC | | Munster Rugby | v | Leinster Rugby | | H |
|
| Thomond Park | RTE/Prem |
|
| January 2022 |
| Sat 1 Jan | 17:15 | URC-IC | | Connacht Rugby | v | Munster Rugby | | H |
|
| Sportsground | TG4/Prem |
|
| Sat 1 Jan | 19:35 | URC-IC | | Ulster Rugby | v | Leinster Rugby | | H |
|
| Kingspan Stadium | Prem/TG4 |
|
| Fri 7 Jan | 19:35 | URC-IC,SAC | | Leinster Rugby | v | Emirates Lions | | H |
|
| RDS Arena | TG4/SS/Prem |
|
| Sat 8 Jan | 17:00 | URC-IC,SAC | | Connacht Rugby | v | DHL Stormers | | H |
|
| Sportsground | RTE/SS |
|
| Sat 8 Jan | 19:35 | URC-IC | | Munster Rugby | v | Ulster Rugby | | H |
|
| Thomond Park | RTE/SS/Prem |
|
| 28/29/30 Jan |
| URC-IC,WC | | Cardiff Rugby | v | Leinster Rugby | | A |
|
| Cardiff Arms Park | S4C/TG4/Pr |
|
| 28/29/30 Jan |
| URC-IC,SIC | | Connacht Rugby | v | Glasgow Warriors | | H |
|
| Sportsground | TG4/Prem |
|
| 28/29/30 Jan |
| URC-IC,WC | | Ulster Rugby | v | Scarlets | | H |
|
| Kingspan Stadium | Prem |
|
| 28/29/30 Jan |
| URC-IC,SIC | | Zebre Parma | v | Munster Rugby | | A |
|
| Stadio Sergio Lanfranchi | It/TG4/Pr |
|
| February 2022 |
| 18/19/20 Feb |
| URC-IC,WC | | Dragons | v | Ulster Rugby | | A |
|
| Rodney Parade | Prem |
|
| 18/19/20 Feb |
| URC-IC,WC | | Leinster Rugby | v | Ospreys | | H |
|
| RDS Arena | TG4/S4C/Prem |
|
| 18/19/20 Feb |
| URC-IC,SIC | | Munster Rugby | v | Edinburgh Rugby |  | H |
|
| TBA | TG4/Prem |
|
| 18/19/20 Feb |
| URC-IC,WC | | Scarlets | v | Connacht Rugby | | A |
|
| Parc y Scarlets | S4C/TG4/Pr |
|
| March 2022 |
| 4/5/6 Mar |
| URC-IC,SIC | | Benetton Rugby | v | Leinster Rugby | | A |
|
| Stadio Monigo | It/TG4/Pr |
|
| 4/5/6 Mar |
| URC-IC,SIC | | Edinburgh Rugby | v | Connacht Rugby | | A |
|
| DAM Health Stadium | Prem/TG4 |
|
| 4/5/6 Mar |
| URC-IC,WC | | Munster Rugby | v | Dragons | | H |
|
| TBA | TG4/S4C/Prem |
|
| 4/5/6 Mar |
| URC-IC,WC | | Ulster Rugby | v | Cardiff Rugby | | H |
|
| Kingspan Stadium | BBC NI/S4/Pr/TG4 |
|
| 25/26/27 Mar |
| URC-IC | | Connacht Rugby | v | Leinster Rugby | | H |
|
| Sportsground | TG4/Prem |
|
| 25/26/27 Mar |
| URC-IC,SAC | | DHL Stormers | v | Ulster Rugby | | A |
|
| Stadium (Green Point) | SS/Prem |
|
| 25/26/27 Mar |
| URC-IC,SIC | | Munster Rugby | v | Benetton Rugby | | H |
|
| TBA | TG4/It/Pr |
|
| April 2022 |
| 1/2/3 Apr |
| URC-IC,SIC | | Benetton Rugby | v | Connacht Rugby | | A |
|
| Stadio Monigo | It/TG4/Pr |
|
| 1/2/3 Apr |
| URC-IC | | Leinster Rugby | v | Munster Rugby | | H |
|
| RDS Arena | TG4/Prem |
|
| 1/2/3 Apr |
| URC-IC,SAC | | Vodacom Bulls | v | Ulster Rugby | | A |
|
| Loftus Versfeld | SS/Prem |
|
| 22/23/24 Apr |
| URC-IC,SAC | | Cell C Sharks | v | Leinster Rugby | | A |
|
| Jonsson Kings Park | SS/TG4/Pr |
|
| 22/23/24 Apr |
| URC-IC,SAC | | Emirates Lions | v | Connacht Rugby | | A |
|
| Emirates Airline Park | SS/TG4/Pr |
|
| 22/23/24 Apr |
| URC-IC | | Ulster Rugby | v | Munster Rugby | | H |
|
| Kingspan Stadium | BBC NI/TG4/Pr |
|
| 29/30 Apr, 1 May |
| URC-IC,SAC | | Cell C Sharks | v | Connacht Rugby | | A |
|
| Jonsson Kings Park | SS/TG4/Pr |
|
| 29/30 Apr, 1 May |
| URC-IC,SAC | | DHL Stormers | v | Leinster Rugby | | A |
|
| Stadium (Green Point) | SS/TG4/Pr |
|
| 29/30 Apr, 1 May |
| URC-IC,SIC | | Edinburgh Rugby | v | Ulster Rugby | | A |
|
| DAM Health Stadium | Prem |
|
| 29/30 Apr, 1 May |
| URC-IC,WC | | Munster Rugby | v | Cardiff Rugby | | H |
|
| TBA | TG4/S4C/Prem |
|
| May 2022 |
| 20/21/22 May |
| URC-IC,SIC | | Connacht Rugby | v | Zebre Parma | | H |
|
| Sportsground | TG4/It/Pr |
|
| 20/21/22 May |
| URC-IC,SIC | | Glasgow Warriors | v | Munster Rugby | | A |
|
| Scotstoun Stadium | Prem/TG4 |
|
| 20/21/22 May |
| URC-IC,SIC | | Leinster Rugby | v | Edinburgh Rugby | | H |
|
| RDS Arena | TG4/Prem |
|
| 20/21/22 May |
| URC-IC,SAC | | Ulster Rugby | v | Cell C Sharks | | H |
|
| Kingspan Stadium | BBC NI/SS/Pr/TG4 |
|
|
